The use of nucleoside and nucleotide analogs to inhibit the viral RNA polymerase, thereby preventing propagation of the virus, is a well-documented and historically successful approach to treatment of various viral diseases, including HIV/AIDS, herpesvirus, hepatitis B and hepatitis C infections.

OUR PURINE NUCLEOTIDE PRODRUG PLATFORM

Uniquely effective against RNA viruses.

Comprising more than 1,000 proprietary prodrugs of nucleoside and nucleotide analogs, Atea’s library of antiviral compounds has provided potent drug candidates that specifically target viral RNA polymerases. Based on extensive knowledge and years of experience discovering and developing antivirals, our team of scientists has designed drug candidates that include specific chemical modifications intended to enhance antiviral activity and maximize selectivity.

Unique prodrugs of nucleotide analogs are intrinsic to Atea’s innovative platform for developing safe, orally administered, direct-acting antiviral therapies.

A graphic illustration of Atea’s different generations of phosphoramidates.

Therapies based on our platform.

AT-527 is the perfect example of the uniqueness of our platform in discovering highly innovative oral nucleotide therapeutics. This sophisticated double prodrug is synthesized as a specific salt form, which required new breakthroughs in our knowledge of medicinal chemistry and cellular pharmacology.

Pipelines & Programs