Committed to the discovery, development and commercialization of oral direct-acting antiviral therapies.

COVID-19

Bemnifosbuvir

Originating from our nucleos(t)ide discovery capabilities, bemnifosbuvir (AT-527) is an oral direct-acting antiviral being evaluated in SUNRISE-3, a global Phase 3 registrational trial for the treatment of COVID-19. In March 2024, Atea completed enrollment of SUNRISE-3 with 2,221 high-risk patients in the bemnifosbuvir monotherapy cohort and 74 patients in the combination cohort. Bemnifosbuvir targets the SARS-CoV-2 RNA polymerase (nsp12), a highly conserved enzyme that is unlikely to change as the virus mutates and new variants continue to emerge. This enzyme is responsible for both transcription and replication of SARS-CoV-2. Bemnifosbuvir has a unique mechanism of action, with dual targets consisting of inhibition of RNA dependent RNA polymerase (RdRp) and nucleotityltransferase (NiRAN) inhibition, which has the potential to create a high barrier to resistance.

HCV

Bemnifosbuvir + ruzasvir

In addition to COVID-19, bemnifosbuvir is also being developed in a Phase 2 clinical trial in combination with ruzasvir, an NS5A inhibitor, for the treatment of hepatitis C virus (HCV). As single agents, both bemnifosbuvir and ruzasvir have demonstrated potent pan-genotypic antiviral activity against HCV.

ATEA PHARMACEUTICALS

Combining innovative discoveries with development expertise to advance antivirals with the potential to transform treatments for patients with serious viral diseases.

Atea is a clinical stage biopharmaceutical company working to address unmet medical needs with innovative oral antiviral therapies.

Advancing Oral Antiviral Therapies with Multibillion Dollar Market Opportunities

COVID-19

Long-term multibillion dollar market opportunity of approximately $4-5+ billion annually

  • Continued demand for innovative oral treatments to address key limitations of current therapies

Hepatitis C (HCV)

HCV continues to be a healthcare crisis with number of new cases exceeding cures— global market in 2023 was approximately >$3 billion in net sales

  • >2 million people in the US are estimated to have HCV
  • ~75% of diagnosed patients in the US are untreated

Innovative Therapies to Address Unmet Medical Needs

COVID-19

Completing global Phase 3 SUNRISE-3 trial evaluating bemnifosbuvir for treatment of COVID-19 in high-risk patients

  • Fast Track designation granted for development of bemnifosbuvir for COVID-19
  • Full patient enrollment for SUNRISE-3 was achieved March 2024
  • 2H’24: Topline results expected

Hepatitis C (HCV)

Executing global Phase 2 combination trial for bemnifosbuvir + ruzasvir in HCV patients

  • 2H’24: Final results expected from Phase 2 trial

Our science.

Leveraging our deep understanding of antiviral drug development, medicinal chemistry, biology, biochemistry and virology, we are discovering and developing novel product candidates to treat single stranded ribonucleic acid, or ssRNA, viruses, which are a prevalent cause of serious viral diseases. Currently, we are focused on the development of orally-available direct-acting antiviral agents for serious viral infections, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19, and HCV.

A network of hubs and spokes is suspended, representing the idea of a modular platform.

COVID-19 AND BEMNIFOSBUVIR

Bemnifosbuvir has the potential to address unmet medical needs for COVID-19.

As the evolution of COVID-19 continues, oral direct-acting antivirals will continue to play an increasingly essential role worldwide. The value and global health impact of conveniently administered direct-acting antivirals is to rapidly inhibit viral replication in the early phase of infection, which has the effect of reducing disease progression.

COVID-19 remains a serious public health threat and there is an urgent need for new oral treatment options to address unmet medical needs and limitations of current therapies.

Bemnifosbuvir is an oral, direct-acting antiviral drug candidate that is being evaluated for COVID-19.

Unmet Medical Need

Limitations of Current Vaccines / Therapies

 

  • Waning immunity of vaccines / natural infection
  • Potential mismatch of vaccine booster to circulating variants
  • Failure to mount immune response to vaccines in some patients
  • No effective monoclonal antibodies for outpatient use
  • Limitations with authorized oral antivirals: drug-drug interactions, safety concerns

Monotherapy

SUNRISE-3 Cohort for Registration

Bemnifosbuvir’s profile addresses key limitations of current therapies

  • Antiviral efficacy against all tested variants of concern
  • Low risk of drug-drug interactions
  • No mutagenicity or embryo-fetal toxicity (preclinical)
  • High barrier to resistance

Combination Therapy

SUNRISE-3 Combination Cohort to Inform Development Strategy

Developing combination therapy for specific COVID-19 patient populations unable to mount immune response

  • Additive benefit indicated in vitro with bemnifosbuvir + DAAs including protease inhibitors (PIs)
  • Advancing internal PI program for combination therapy with bemnifosbuvir

NEWS

Follow our progress.

Updates on bemnifosbuvir, other Atea product candidates and company news.

Atea Pharmaceuticals Presents New Data Showcasing Potential Best-in-Class Combination Profile of Bemnifosbuvir and Ruzasvir for Treatment of Hepatitis C Virus at EASL Congress 2024

Presentations to Include New Antiviral Efficacy Results, Including SVR12 Data, from Lead-In Cohort of Ongoing Phase 2 HCV Trial Data Also Highlight the High Prevalence of Pre-Existing NS5A Resistance-Associated Substitutions (RAS) Detected in HCV-infected Patients BOSTON, May 22, 2024 (GLOBE

Atea Pharmaceuticals Reports First Quarter 2024 Financial Results and Provides Business Update

Full Enrollment Achieved in Global Phase 3 SUNRISE-3 Trial for Treatment of COVID-19 with Results Expected 2H’24 Global Phase 2 HCV Study On Track to Report Complete SVR12 Results 2H’24 Multiple Presentations Showcasing Preclinical and New Phase 2 Efficacy Data to be Presented at European

Atea Pharmaceuticals to Host First Quarter 2024 Financial Results Conference Call on May 14, 2024

BOSTON, Mass., May 07, 2024 (GLOBE NEWSWIRE) -- Atea Pharmaceuticals, Inc. (Nasdaq: AVIR) (“Atea”), a clinical-stage biopharmaceutical company engaged in the discovery and development of oral antiviral therapeutics for serious viral diseases, today announced that it will host a live conference call